Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice
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چکیده
منابع مشابه
Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice.
Mitochondrial DNA (mtDNA) deletion mutations are proposed contributors to aging-related muscle fiber loss and atrophy, but evidence of a causal role for these mutations in muscle aging is lacking. Elucidating the etiology of in vivo mtDNA deletion mutations will help to better understand and test the possible roles of these mutations in aging. The implication of mtDNA mutations in aging is base...
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Reactive oxygen species have been implicated as a cause of cancer and aging in mammals. Mice deficient for the antioxidant enzyme CuZn-superoxide dismutase (Sod1) have a decreased life span and an elevated incidence of liver cancer. To test the hypothesis that the cancer-prone phenotype in such mice is due to accelerated spontaneous mutation accumulation, we crossed these mutants with mice harb...
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ژورنال
عنوان ژورنال: Experimental Gerontology
سال: 2015
ISSN: 0531-5565
DOI: 10.1016/j.exger.2014.11.012